Rendine started his musical studies at the age of five with his father, Furio Rendine (1920–1987) and his grandfather Salvatore Papaccio (1890–1977). He was pupil of Domenico Guaccero at the Santa Cecilia Conservatory in Rome and of Giuseppe Agostini at Pesaro Conservatory. Professor at the Conservatorio “A. Casella” in L’Aquila. he sat on the board of directors of the Accademia Nazionale di Santa Cecilia and artistic director of the Teatro Marrucino in Chieti from 1997 to 2007.

His works were commissioned by BBC London, Suddeusher Rundfunk Studtgard, Northdeuth Rundfunk Hamburg, Koln Philharmonie, Montecarlo Opera House, Rome Teatro dell’Opera, Naples Teatro San Carlo, Bologna Teatro Comunale, Arena di Verona, La Scala, Radio Symphony Orchestra of Italy, Salzburg Music Festival, Strasbourg Festival, Swetzingen Festspiele.

His compositions have been performed by famous artists as Vladimir Ashkenazy, José Carreras, Carla Fracci, Lindsey Kemp, Katia Ricciarelli, Gianluigi Gelmetti, Salvatore Accardo, Marzio Conti.

Together with Yoritsune Matsudaira, Gian Carlo Menotti, Krzysztof Penderecki and Alfred Schnittke, Rendine was commissioned by the Nobel Peace Prize Committee to compose the Mass for Peace, which was performed at the Nobel Peace Prize Concert in Oslo on 11 December 1995.

He won Prix Italia and Premios Ondas with “Alice” in 1987–1988.