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The favorite instrument of Francesco Landini was the portative organ, or organetto. In his childhood, he apparently contracted and survived smallpox, but the disease left him blind for the rest of his life. He was well-versed in the playing of several instruments, but his favourite instrument was the portative organ, or organetto. His playing, poetry and music (of which 150 works remain) were admired by Petrarch and by Peter the Great, King of Cyprus.
This information is drawn from The Organ, by William Leslie Sumner.